What is in dupixent?

What ingredients are in Dupixent?

Dupixent (dupilumab) is a biologic medicine. Its active ingredient is dupilumab, a fully human monoclonal antibody [1].

What is dupilumab made from?

Dupilumab is an antibody designed to target the IL-4 and IL-13 signaling pathways by binding to the IL-4 receptor alpha subunit (IL-4Rα) [1]. This is the key mechanism behind Dupixent’s use in diseases such as moderate-to-severe eczema (atopic dermatitis), asthma, chronic rhinosinusitis with nasal polyps, and other approved indications [1].

What else is in the medicine besides the active ingredient?

Like other injectable biologics, Dupixent includes inactive ingredients (excipients) in addition to dupilumab, but the exact list can depend on the formulation and presentation (for example, syringe vs. pen). The most reliable place to confirm the specific inactive ingredients for your exact product is the package insert or the manufacturer’s full prescribing information [1].

How should patients interpret “what’s in it” for allergy or side-effect concerns?

Because Dupixent is an injection containing a monoclonal antibody plus excipients, people with known sensitivities to components of injectable biologics should review the product’s prescribing information. If you’re asking because of an allergy concern, tell a clinician which Dupixent presentation you’re using so the exact excipients can be checked.

Sources:
1. https://www.drugs.com/dupixent.html