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Keep Humira pens in their original carton in a refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze them—freezing makes them unusable. Protect from light by leaving them in the carton.1
Before first use, unrefrigerated pens can stay at room temperature up to 77°F (25°C) for a maximum of 14 days total (including any prior room-temp time). Track this period and discard if exceeded. After first use, store at room temperature up to 77°F (25°C) for up to 21 days, or refrigerate again if below 77°F.1
Do not use a frozen pen—return it for a replacement. Pens exposed above 77°F (25°C) beyond allowed times should be discarded. Avoid direct sunlight, heat sources, or car interiors without cooling.1
For flights, pack in carry-on with a cooler bag and ice packs (not touching pens). Include a doctor's note for TSA. Some pharmacies provide travel kits. Always check the pen's label for expiration and inspect for damage before injecting.1 [1]: https://www.humira.com/humira-complete/global/humira-storage
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