Can You Take Melatonin with Lisinopril?
No known interactions exist between melatonin and lisinopril. Lisinopril, an ACE inhibitor for high blood pressure, and melatonin, a hormone supplement for sleep, do not affect each other's metabolism or blood levels based on drug interaction databases.[1][2]
What Do Major Databases Say?
Drugs.com reports no interactions, listing both as safe to combine.[1] WebMD and RxList confirm this, with no warnings for additive effects on blood pressure or drowsiness.[2][3] A review in the Journal of Clinical Sleep Medicine found no adverse events in patients using melatonin alongside antihypertensives like lisinopril.[4]
Does It Affect Blood Pressure?
Melatonin may slightly lower blood pressure in some people, but studies show it does not amplify lisinopril's effects or cause hypotension when combined. Monitor your readings if concerned, especially at higher melatonin doses (over 5mg).[5]
Timing and Dosage Tips
Take melatonin 30-60 minutes before bed; lisinopril timing (morning or evening) does not conflict. Start with 1-3mg melatonin to assess tolerance. Avoid alcohol, which can enhance sedation from either.[1][2]
When to Talk to Your Doctor
Consult if you have kidney issues, as lisinopril affects renal function and melatonin clearance is partly kidney-dependent. Rare reports note dizziness in elderly users, though not linked directly to the pair.[3] Pregnant or breastfeeding individuals should avoid melatonin.
[1]: Drugs.com - Lisinopril and Melatonin Interaction
[2]: WebMD - Melatonin Interactions
[3]: RxList - Lisinopril Interactions
[4]: Journal of Clinical Sleep Medicine - Melatonin and Antihypertensives
[5]: American Journal of Hypertension - Melatonin BP Effects