Vascepa is a prescription medication that contains the active ingredient icosapent ethyl, which is a type of omega-3 fatty acid. It is used to treat high levels of triglycerides in the blood, which is a type of fat that can increase the risk of heart disease. According to the drug label [3], Vascepa should be taken with food to increase its absorption and reduce the risk of stomach upset. However, the label does not provide specific guidance on how Vascepa interacts with high-fat foods.

A study published in the Journal of Cardiovascular Pharmacology and Therapeutics [2] evaluated the effect of a high-fat meal on the pharmacokinetics of Vascepa. The study found that taking Vascepa with a high-fat meal did not significantly affect the absorption of the medication. The authors concluded that Vascepa can be taken with or without food, and there is no need to avoid high-fat foods when taking this medication.

Another source [1] provides information on the patent for Vascepa, but it does not offer any information on how the medication interacts with high-fat foods.

In summary, the available sources suggest that taking Vascepa with high-fat foods does not significantly affect the absorption of the medication. The drug label recommends taking Vascepa with food to increase its absorption and reduce the risk of stomach upset. However, it does not provide specific guidance on how Vascepa interacts with high-fat foods. It is always important to consult with a healthcare provider or pharmacist for personalized advice on how to take medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379293/
[3] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202057s019lbl.pdf