How to Use Gvoke HypoPen in a Hypoglycemia Emergency
Gvoke HypoPen delivers glucagon to treat severe low blood sugar (hypoglycemia) when someone is unconscious or unable to swallow. It's a prefilled, needle-free auto-injector for adults and kids 2+ years. Follow these steps exactly during an emergency—act fast as symptoms like confusion or seizures can worsen quickly.[1][2]
1. Check the dose window: Flip off the gray cap. Confirm the dose window shows a full dose (75 mg for adults/90+ kg; 1.65 mg or 3 mg for others based on weight/age). Do not use if it's empty, frozen, expired, or damaged.[1]
2. Press against thigh: Hold the black base firmly against the bare upper outer thigh (through clothing if needed). Press down hard for 5 seconds—count it out. You'll hear a click and see the green safety guard cover the nozzle.[1][2]
3. Remove and observe: Lift the HypoPen away. The injection is done; no needle to handle.[1]
What Happens After Injection and Next Steps
Glucagon raises blood sugar within 15 minutes by prompting liver glucose release. If no response in 15 minutes, give a second dose (kit allows two).[1]
- Call 911 immediately after first dose—hospital care is often needed.
- Once alert, give fast-acting carbs (15g like juice/glucose tabs), then a snack. Recheck blood sugar every 15 minutes.
- Mild side effects: nausea, vomiting. Seek medical help for breathing issues or allergic reactions.[2]
Storage, Shelf Life, and Common Mistakes to Avoid
Store at room temperature (68-77°F), away from heat/sunlight; expires 12 months after first use (track date on label).[1]
Avoid:
- Injecting arm/buttocks (thigh only).
- Using if >12 months old or after yellow indicator shows.
- Sharing—single-patient use.[1][2]
Practice with trainer pen (no needle/glucagon) for confidence. Prescribe for at-home emergencies.[2]
Who Should Use It and When to Replace
For severe hypoglycemia unresponsive to oral carbs. Replace after use/expiry; keep backup. Kids under 2 need different dosing—consult doctor.[1]
[1] Gvoke HypoPen Prescribing Information, Xeris Pharmaceuticals, https://www.gvokeglucagon.com/hypopen
[2] FDA Medication Guide for Gvoke, https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/212978s009lbl.pdf