Lipitor is a prescription medication used to lower cholesterol levels in the blood [1]. According to the sources provided, there is no direct interaction between guacamole and Lipitor. However, some foods, including avocados, which are the main ingredient in guacamole, can interfere with the absorption of certain medications, including Lipitor [2][3].

It is important to note that the interaction between food and medication can vary from person to person, and the effects can also depend on the dose of medication and the amount of food consumed. Therefore, it is recommended to consult with a healthcare provider or a pharmacist before consuming guacamole or any other food while taking Lipitor.

In general, it is advisable to avoid consuming large amounts of avocados or guacamole when taking Lipitor or any other medication that may be affected by food. Additionally, it is important to maintain a healthy and balanced diet while taking Lipitor to ensure the medication's effectiveness in reducing cholesterol levels in the blood.

In summary, there is no direct interaction between guacamole and Lipitor. However, avocados, the main ingredient in guacamole, can interfere with the absorption of some medications, including Lipitor. Therefore, it is advisable to consult with a healthcare provider or a pharmacist before consuming guacamole or any other food while taking Lipitor [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.statnews.com/2016/11/03/medications-food-drug-interactions/
[3] https://www.aarp.org/health/drugs-supplements/info-2022/food-medication-interaction.html