How is Vivitrol (naltrexone) supposed to be injected?
Vivitrol is given as an extended-release injection into muscle (intramuscular, IM). It is not a pill and it is not meant for subcutaneous (under the skin) or IV (into a vein) use.
Because the injection is a depot formulation, the technique and preparation matter. If you’re not a trained clinician following the product’s instructions, you should not attempt to inject it yourself.
Where is it injected (site and technique)?
Clinically, Vivitrol is administered deep IM, typically into the gluteal (buttock) muscle. The usual practice is to alternate injection sites if multiple doses are needed.
A proper IM injection requires correct needle length, correct angle, and correct handling of the suspension so the dose is delivered correctly.
How often is Vivitrol injected?
Vivitrol is commonly prescribed as a monthly injection (every 4 weeks) for alcohol use disorder and opioid use disorder maintenance treatment.
What must be checked before the first injection?
Before starting Vivitrol, clinicians check that the person is not actively using opioids and has no signs of opioid withdrawal, because naltrexone can precipitate withdrawal in someone with opioids in their system.
For people starting treatment, prescribers may use an opioid-free interval and/or other assessment steps per clinical practice and product guidance.
What can go wrong if it’s injected incorrectly?
Incorrect route or poor technique can lead to:
- Failed dosing (less medication delivered than intended)
- Local complications at the injection site (pain, swelling, lumps, infection risk)
- Higher risk of adverse effects from improper administration
Because of these risks, Vivitrol should only be administered by a clinician or a trained caregiver following the official prescribing information and injection instructions.
If you tell me your situation, I can point you to the right instructions
Are you asking for instructions because you (1) are a healthcare professional, (2) are a caregiver, or (3) are a patient trying to self-inject? Also, is this for alcohol use disorder or opioid use disorder?