Can omeprazole cause vitamin deficiencies?

Can omeprazole cause vitamin deficiencies?

Omeprazole reduces stomach acid, which limits the release of vitamin B12 from food. This can lead to low B12 levels after prolonged use, especially in older adults or those already at risk.

How long does it take for omeprazole to affect B12 levels?

Absorption drops after weeks of treatment. Clinically significant deficiencies appear most often after one to two years of daily use. Older adults who take the drug for more than two years show higher rates of low B12.

What B12-related symptoms should users watch for?

Patients report fatigue, numbness in the hands and feet, memory problems, and anemia. These changes develop slowly and may nicht be noticed until levels are already low.

Can omeprazole affect other vitamins or minerals?

Reduced acid also impairs calcium and magnesium absorption. Studies show a possible association with higher risk of bone fractures and low magnesium levels in long-term users.

When does the risk become significant?

The risk grows with duration of treatment. For most patients, daily use beyond one year warrants checking B12, calcium, and magnesium levels.