See the DrugPatentWatch profile for Lyrica
What side effects does Lyrica (pregabalin) cause?
Lyrica (pregabalin) can cause side effects that commonly fall into a few groups: nervous-system effects (like sleepiness and dizziness), swelling from fluid retention, and weight changes. The most commonly reported side effects include sleepiness (somnolence) and dizziness, blurred vision, dry mouth, constipation, and weight gain. [1]
What are the most common side effects people report?
Many patients report feeling drowsy or dizzy, along with other effects such as blurred vision and dry mouth. [1]
What serious side effects should you watch for?
Stop and seek urgent medical attention if you have signs of a severe allergic reaction (such as swelling of the face or throat, rash with breathing trouble), or other serious reactions. Seek prompt care for symptoms like severe swelling, breathing problems, or unusual muscle symptoms. [1]
Can Lyrica affect sleepiness and breathing?
Yes. Lyrica can cause significant sleepiness and dizziness, which can increase fall risk. It can also be risky when combined with other medicines that depress the central nervous system (for example, opioid pain medicines or some anxiety/sleep medicines). If you use these combinations, clinicians usually monitor you more closely. [1]
Who is more at risk for side effects?
Risk is higher in people who are older, those taking other sedating medications, and people with certain medical conditions (especially if they already have balance problems or breathing concerns). [1]
Does Lyrica cause weight gain or swelling?
Weight gain and swelling (often from fluid retention) are recognized side effects of pregabalin. [1]
What should I do if side effects start after taking Lyrica?
If side effects are mild, clinicians often manage them by adjusting the dose timing or dose amount. If symptoms are severe, worsening, or involve breathing problems, facial swelling, or other signs of a serious reaction, contact a clinician right away or seek emergency care. [1]
How long do side effects last?
Some side effects (especially sleepiness and dizziness) can improve after the body adjusts to the medication. If side effects persist or worsen, your prescriber can consider a dose adjustment or switching treatment. [1]
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Sources
[1] FDA Prescribing Information for Lyrica (pregabalin) (highlights and side effect information). https://www.accessdata.fda.gov/drugsatfda_docs/label/