Vascepa (icosapent ethyl) is a prescription medication used to treat high levels of triglycerides in the blood. According to the sources provided, there are some potential side effects of combining Vascepa with other medications.

Firstly, it is important to note that before combining Vascepa with any other medication, patients should consult their healthcare provider. This is because certain medications may interact with Vascepa and cause harmful side effects.

According to Drugs.com [2], there are 141 drugs that may interact with Vascepa. Some of these drugs include blood thinners, such as warfarin, and other medications used to treat high cholesterol, such as atorvastatin and simvastatin. The combination of Vascepa with these medications may increase the risk of bleeding and may also cause muscle pain and weakness.

Mayo Clinic [3] also notes that combining Vascepa with certain cholesterol-lowering medications, such as fibrates, may increase the risk of serious muscle problems. Therefore, it is important to inform your healthcare provider about all the medications you are taking before starting Vascepa.

It is also important to note that Vascepa itself may cause some side effects. According to Drug Patent Watch [1], some common side effects of Vascepa include joint pain, swelling, and stiffness, as well as back pain, constipation, and diarrhea. In rare cases, Vascepa may also cause an allergic reaction.

In conclusion, while Vascepa is generally safe and effective, it is important to consult your healthcare provider before combining it with any other medication. Some medications may interact with Vascepa and cause harmful side effects. Additionally, Vascepa itself may cause some side effects, which should be monitored by your healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.drugs.com/drug-interactions/icosapent,vascepa.html
[3] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/cholesterol-medications/art-20050958