Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while salt substitutes are used to reduce sodium intake in the diet. The interaction between these two medications is not well established, but there are some potential concerns to consider.

According to the Drug Patent Watch [1], there are no known drug interactions between Lipitor and salt substitutes. However, salt substitutes contain potassium chloride, which can increase potassium levels in the blood. High potassium levels can be dangerous, especially for people with kidney disease or those taking certain medications, such as ACE inhibitors, potassium-sparing diuretics, and potassium supplements. Lipitor itself does not affect potassium levels, but it is important to monitor potassium levels if you are taking a salt substitute while on Lipitor.

Additionally, according to US Pharmacist [2], some salt substitutes may contain magnesium, which can interfere with the absorption of certain medications, including Lipitor. It is recommended to take Lipitor at least two hours before or four hours after taking magnesium-containing supplements or antacids.

The American Heart Association [3] also warns that some salt substitutes may contain hidden sources of sodium, such as baking soda or sodium bicarbonate, which can increase blood pressure and counteract the effects of Lipitor. Therefore, it is important to read the labels carefully and choose a salt substitute that is low in sodium and does not contain any other ingredients that may interact with Lipitor.

In summary, while there are no known drug interactions between Lipitor and salt substitutes, it is important to monitor potassium levels and avoid salt substitutes that contain magnesium or hidden sources of sodium. Always talk to your healthcare provider before taking any new medications or supplements, including salt substitutes, while on Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.uspharmacist.com/article/drug-interactions-with-vitamins-and-minerals
[3] https://www.heart.org/en/health-topics/consumer-healthcare/medication-information/medication-interactions-food-supplements-and-other-drugs