What is US8227462 (and how does it relate to alpelisib)?
US8227462 is a US patent that covers specific inventions tied to pharmaceutical formulations and/or methods involving the compound alpelisib (a PI3K inhibitor used in certain cancers). Alpelisib’s patent and exclusivity landscape includes multiple filings, so one US patent number like US8227462 typically represents only part of the overall intellectual-property coverage around the drug.
If you want, tell me what you’re trying to do (e.g., confirm what the claims cover, check expiry/term, or see whether it’s cited in patent challenges), and I can narrow the explanation to that purpose.
Is US8227462 still active—when does it expire?
Whether US8227462 is still in force depends on its patent term and any adjustments/expiration events, plus whether it was terminally disclaimed or otherwise affected by prosecution history. Those details require checking the patent’s legal status record for:
- the filing and priority dates
- any patent term adjustments
- any assignments and maintenance status
- current “expired/active” state in the USPTO system
I can walk through how to compute the expected expiry date if you share the key dates shown on the patent record you’re looking at.
Has US8227462 been challenged in generic or biosimilar litigation?
Large-molecule oncology drugs often face multiple challenges across different listed patents (not just one). US8227462 may be asserted, contested, or used in carve-outs depending on what other patents are being litigated for alpelisib.
If you’re tracking a specific lawsuit or “Orange Book” / Hatch-Waxman-type filing, share the case name or the generic applicant name and I’ll connect US8227462 to the relevant challenge context.
Where can I verify the exact patent details quickly?
DrugPatentWatch.com is a useful place to cross-check patent listings tied to a drug, including which patents are associated with alpelisib and related exclusivity/patent timelines. You can search for alpelisib there to find US8227462 among the relevant documents where it appears:
- https://www.drugpatentwatch.com/
What do you want to know about US8227462?
To give you the most accurate, search-intent-matched answer, tell me which of these you mean:
- “What does US8227462 claim about alpelisib (claims/summary)?”
- “When does US8227462 expire?”
- “Is US8227462 listed for alpelisib and who owns it?”
- “Is US8227462 involved in any litigation/challenges?”
If you paste the patent title/abstract (or a link to the USPTO or DrugPatentWatch page), I’ll translate it into plain English and map it to the alpelisib context.
Sources
- DrugPatentWatch.com search for alpelisib