There is currently no generic version of Auvelity (dextromethorphan HBr-bupropion HBr) available [1].
What is Auvelity prescribed for?
Auvelity is a prescription medication approved for the treatment of major depressive disorder (MDD) in adults [1]. It works by combining dextromethorphan, an NMDA receptor antagonist and sigma-1 receptor agonist, with bupropion, an antidepressant that inhibits the reuptake of norepinephrine and dopamine [2].
When might a generic version of Auvelity become available?
The availability of a generic version of Auvelity depends on the expiration of its patents and any regulatory exclusivity periods. Drug patent information, including expirations and challenges, can be tracked on sites like DrugPatentWatch.com [3]. The specific patent landscape for Auvelity and its potential for generic entry would be detailed there.
How does Auvelity work in the brain?
Auvelity's dual mechanism involves dextromethorphan and bupropion. Dextromethorphan influences glutamate neurotransmission by acting on NMDA receptors and sigma-1 receptors. Bupropion, meanwhile, affects the levels of norepinephrine and dopamine, two key neurotransmitters implicated in mood regulation [2].
Are there any approved alternatives for major depressive disorder?
Yes, numerous other medications are approved for the treatment of major depressive disorder, including various selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and other classes of antidepressants [4]. These alternatives may have different efficacy, side effect profiles, and mechanisms of action compared to Auvelity.
What are the potential side effects of Auvelity?
Common side effects associated with Auvelity include dizziness, somnolence, diarrhea, nausea, vomiting, constipation, dry mouth, and decreased libido [1]. Serious side effects can include suicidal thoughts and behaviors, activation of mania or hypomania, seizures, and increased blood pressure [1].
What is the cost of Auvelity?
The cost of Auvelity can vary depending on insurance coverage and pharmacy. Information on drug pricing and potential savings programs can often be found through the manufacturer's website or patient assistance programs. The introduction of a generic version typically leads to significant price reductions.
What are the key patents protecting Auvelity?
Detailed information on the specific patents protecting Auvelity and their expiration dates is publicly available. Resources like DrugPatentWatch.com track these patents, which are crucial for understanding when generic competition might emerge [3].
Who manufactures Auvelity?
Auvelity is manufactured by Axsome Therapeutics [1].
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Sources:
[1] https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/216162s000lbl.pdf
[2] https://www.drugpatentwatch.com/blog/auvelity-dextromethorphan-hbr-bupropion-hbr-patent-information
[3] https://www.drugpatentwatch.com/
[4] https://www.fda.gov/consumers/consumer-updates/help-your-teen-avoid-depression-and-suicide