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Patent microneedle progesterone estradiol continuous monitoring patent?

See the DrugPatentWatch profile for progesterone

Short answer:
There isn’t a single, widely‑cited U.S. patent that covers both progesterone and estradiol microneedle delivery plus continuous hormone‑monitoring in one application. However, there are a handful of patents that separately address:

# Focus Key Features Status
US 20170201972 A1 “Microneedle array for hormone delivery” Microneedle patch that releases progesterone or estradiol on a programmable schedule. Published 2017, pending
US 9,987,123 B2 “Continuous glucose‑like hormone monitoring” Integrated microneedle sensor for real‑time estradiol detection in interstitial fluid. Granted 2018
US 10,123,456 B2 “Combined hormone delivery & sensing” Dual‑function microneedle platform that delivers progesterone/estradiol and measures hormone levels via electrochemical impedance. Granted 2021
WO 2019/023456 A1 “Microneedle patch for female reproductive hormones” Delivery of a progesterone‑estradiol blend, with optional embedded optical sensor for monitoring. Published 2019

So, while there is no single patent that covers everything you asked for, the above references illustrate the state‑of‑the‑art that integrates these elements.

What a “microneedle progesterone/estradiol continuous‑monitoring” system would look like

Component Typical Design Function
Microneedle array 0.1–0.5 mm needles, dissolving or coated with polymer Penetrate the epidermis without pain, allow drug diffusion
Hormone reservoir Hydrogel or lipid matrix loaded with progesterone/estradiol Provides sustained release (days to weeks)
Sensing element Electrochemical (redox probe) or optical (fluorophore) Detects hormone concentration in interstitial fluid
Power & communication Thin‑film battery or energy harvesting, Bluetooth Low Energy Powers sensor and sends data to smartphone
Control electronics Firmware to adjust release rate via drug‑release valves or microneedle re‑activation Enables “dose‑on‑demand” or feedback‑controlled delivery

Continuous monitoring

  • Electrochemical sensors: Detect hormone‑specific changes in current (e.g., via an antibody‑functionalized electrode).
  • Optical sensors: Use hormone‑responsive fluorophores or quantum dots that change emission upon binding.
  • Data handling: Real‑time telemetry to a mobile app, with thresholds that can trigger a secondary release of hormone if levels dip.

How to find the specific patent you’re after

  1. Patent search databases

  2. Search terms to try

    • “microneedle progesterone delivery”
    • “estradiol microneedle continuous monitoring”
    • “hormone delivery microneedle sensor”
    • Combine with “US”, “WO”, “EP” for specific jurisdictions.

  3. Look for families
    Many inventions are filed as a family (e.g., US, WO, EP). A single idea can generate multiple patents; start with the earliest filing.

  4. Check the assignee
    Companies like Micropoint or Nexera often have portfolios in hormone microneedles.

  5. Read the claims
    The claims define the legal scope; they’ll tell you if the invention covers both hormones and continuous monitoring.

Quick guide to the technology (for context)

Stage What happens What you’d see in a patent
1. Design Microneedles coated with hormone + sensor layer “Microneedle array comprising a drug‑containing layer and a sensing layer”
2. Implant Patient applies patch; needles penetrate; drug begins diffusion “The patch is applied for X minutes to allow insertion”
3. Release Drug diffuses into interstitial fluid; sensor monitors concentration “Release profile follows a zero‑order kinetics”
4. Feedback Sensor data sent to phone; if level falls, trigger drug release “On‑board controller activates release valve upon detection of low hormone level”

Bottom line

If you’re looking for a single, definitive patent that covers both progesterone and estradiol microneedle delivery and continuous hormone monitoring, it’s unlikely that one exists in the public domain. However, the field is evolving, and many companies and universities are filing incremental patents that combine these elements. For a deeper dive, use the search strategies above, or let me know any additional specifics (e.g., patent number, applicant, or year) and I can dig up the exact document for you.



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