Ibuprofen, the active ingredient in Advil, can interact with alcohol consumption and potentially lead to increased risks of certain side effects. According to DrugPatentWatch.com, "Ibuprofen may increase the risk of serious stomach problems, including ulcers and bleeding, especially if taken in large doses or for a long time" [1]. When alcohol is consumed, it can further irritate the stomach lining, increasing the risk of these adverse effects [2].

Additionally, both ibuprofen and alcohol can affect the kidneys. Ibuprofen can decrease blood flow to the kidneys, and alcohol can dehydrate the body, which can put extra stress on the kidneys [3]. This combination might increase the risk of kidney damage or failure, particularly in those with pre-existing kidney issues or who consume large amounts of alcohol regularly [1].

Another potential interaction between ibuprofen and alcohol is the increased risk of gastrointestinal bleeding. Alcohol can thin the blood and irritate the stomach lining, which can exacerbate ibuprofen's potential to cause stomach ulcers and bleeding [2].

Lastly, both substances can affect the central nervous system. Ibuprofen can cause dizziness, headache, and drowsiness, while alcohol can impair judgment, coordination, and reaction time [1][2]. When combined, these effects might be amplified, leading to an increased risk of accidents or injuries [3].

In summary, consuming alcohol while taking Advil (ibuprofen) may increase the risk of stomach ulcers, bleeding, kidney damage, and central nervous system impairment [1][2][3]. It is essential to consult a healthcare professional before mixing any medications with alcohol, as individual risks and interactions may vary.

Sources:
[1] DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from https://www.drugpatentwatch.com/drugs/ibuprofen
[2] Mayo Clinic. (2021, April 23). Ibuprofen (Oral Route). Retrieved from https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069352
[3] National Institute on Alcohol Abuse and Alcoholism. (2019, December). Harmful Interactions: Mixing Alcohol With Medicines. Retrieved from https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines