Azathioprine is an immunosuppressant medication used to prevent organ rejection after a transplant and to treat autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, and multiple sclerosis [1]. It is available under several brand names, including Imuran and Azasan [1].
What is the typical cost of Azathioprine?
The cost of Azathioprine can vary. For example, GoodRx shows that the average cash price for 60 tablets of 50mg Azathioprine is around $30-$40, but prices can be as low as $10 with a GoodRx discount [2]. However, prices are subject to change and depend on the pharmacy and available discounts.
How does Azathioprine work?
Azathioprine is a prodrug, meaning it is converted in the body to its active form, 6-mercaptopurine (6-MP) [1]. 6-MP interferes with DNA and RNA synthesis, which slows down the growth of rapidly dividing cells, including immune cells [1]. This reduction in immune cell activity helps prevent the body from attacking its own tissues in autoimmune diseases and from rejecting a transplanted organ [1].
When does the patent for Azathioprine expire?
Azathioprine is a well-established drug and its original patents have long since expired [3]. This means generic versions of the medication are available, contributing to lower costs [3].
What are the potential side effects of Azathioprine?
Common side effects of Azathioprine can include nausea, vomiting, diarrhea, and hair loss [1]. More serious side effects can involve bone marrow suppression, leading to a decreased white blood cell count, increased risk of infection, and anemia [1]. Liver damage is another potential concern [1]. Patients taking Azathioprine require regular monitoring of blood counts and liver function [1].
Who manufactures Azathioprine?
Several pharmaceutical companies manufacture Azathioprine. These include brands like Imuran, produced by Marathon Pharmaceuticals, and Azasan, manufactured by Salix Pharmaceuticals [1]. Generic versions are also widely available from various manufacturers.
How does Azathioprine compare to other immunosuppressants?
Azathioprine is one of many immunosuppressant medications available. Its use is determined by the specific condition being treated and the patient's individual response. Other immunosuppressants might have different mechanisms of action, side effect profiles, or indications. For instance, drugs like methotrexate are also used for rheumatoid arthritis, while others like tacrolimus are more common in transplant medicine. The choice of immunosuppressant is a clinical decision made by a healthcare provider.
What should patients know before starting Azathioprine?
Patients starting Azathioprine should discuss their full medical history with their doctor, including any history of infections, liver or kidney problems, or bone marrow issues [1]. It is crucial to inform the doctor about all other medications being taken, including over-the-counter drugs and supplements, as Azathioprine can interact with other substances [1]. Regular blood tests are essential to monitor for side effects [1].
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Sources:
[1] Drugs.com
[2] GoodRx
[3] DrugPatentWatch.com