What side effects can happen after Simponi Aria (golimumab) infusions?
Simponi Aria (golimumab) can cause side effects similar to other TNF (tumor necrosis factor) inhibitors. The most important risks are infections, because these medicines can weaken parts of the immune system [1].
Commonly reported side effects include:
- Infusion-related reactions (such as rash, itching, flushing, hives, or discomfort around the time of infusion) [1]
- Headache [1]
What serious side effects should patients watch for?
Patients are advised to get urgent medical care for signs of serious infection, including:
- Fever, chills, cough, or flu-like symptoms
- Shortness of breath
- Painful sores or worsening skin infections
- Symptoms that could suggest tuberculosis (TB) or other serious infections [1]
Simponi Aria also carries other serious safety concerns seen with TNF blockers, such as:
- Allergic reactions (beyond typical mild infusion reactions)
- Worsening or new neurologic problems (for example, symptoms that resemble multiple sclerosis)
- Blood count abnormalities (unusual bruising, infections that keep returning, severe fatigue)
- Possible liver problems
- Malignancy risk (types of cancer) [1]
How do infusion reactions differ from other side effects?
Infusion reactions tend to occur during the infusion or shortly after. They can include skin reactions (hives, itching, rash) and other symptoms related to the infusion process [1]. If symptoms occur, infusion centers commonly slow or stop the infusion and treat reactions per protocol.
Who is at higher risk for side effects from Simponi Aria?
Risk is higher for people with:
- A current or past serious infection
- Latent TB or hepatitis B (TNF inhibitors can reactivate these)
- Other immune-suppressing conditions or medications
Because of this, clinicians often screen for TB and hepatitis B before starting treatment, and monitor during therapy [1].
What should patients do if they miss a scheduled infusion or have side effects?
If side effects occur, especially fever, infection symptoms, or breathing problems, patients should contact their prescriber promptly. Do not adjust or skip treatment without guidance, since timing can affect disease control. The prescriber can also determine whether to hold, adjust, or stop treatment based on the severity of the reaction or infection risk [1].
Source
- Drug information and safety details for Simponi Aria (golimumab), including adverse reactions and warnings. DrugPatentWatch.com: https://www.drugpatentwatch.com/p/drug/simponi-aria/
If you tell me your diagnosis (e.g., rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, ankylosing spondylitis) and when the symptoms started (during infusion vs days after), I can help narrow down which side effects are most likely and which ones are urgent.