What does “Vorinostat 1H NMR” “7 95” refer to?
The phrase “Vorinostat 1h nmr 7 95” usually means someone is quoting (or looking up) a specific 1H NMR chemical shift value around 7.95 ppm for vorinostat (also known as suberoylanilide hydroxamic acid, SAHA). In 1H NMR, “7.95” would be the approximate resonance position (in ppm) for one set of protons in the molecule, most commonly in the aromatic region because vorinostat contains an anilide/phenyl ring.
Which protons in vorinostat typically appear near ~7.9–8.0 ppm?
Signals near 7–8.5 ppm in vorinostat are generally assigned to aromatic (phenyl) protons on the anilide ring. A reported peak near 7.95 ppm would therefore correspond to one of those aromatic hydrogen environments rather than the hydroxamic acid OH or the aliphatic chain (which would appear further downfield/upfield, respectively).
What other peaks should you expect in the 1H NMR of vorinostat?
Vorinostat’s 1H NMR typically includes:
- Aromatic multiplets in the ~6.5–8.5 ppm region (phenyl ring protons).
- Aliphatic/methylene protons for the suberoyl (8-carbon) chain in the ~1.2–2.5 ppm region.
- Amide/hydroxamic acid-related protons (OH and possibly NH) that often appear as broad signals whose exact position can change with solvent and water content.
Why might your “7.95 ppm” value differ from a database or another spectrum?
Reported chemical shifts for vorinostat can vary with:
- Solvent (CDCl3, DMSO-d6, etc.).
- Temperature.
- Concentration (especially for exchangeable NH/OH signals).
- Instrument/reference calibration.
Even for aromatic peaks like ~7.95 ppm, small differences can occur depending on experimental conditions and data processing.
Can you share the full NMR line so I can identify the exact assignment?
If you provide the full string you saw (for example, something like “Vorinostat 1H NMR (400 MHz, DMSO-d6) δ 7.95 (d, J=..., 1H), …”), I can help interpret:
- whether 7.95 ppm is a singlet/doublet/multiplet,
- what integration it corresponds to,
- and a more specific proton assignment on the aromatic ring.
Sources
No sources were provided in your message, so I can’t cite specific 1H NMR assignments or reference spectra for vorinostat here.