Nystatin 100 000 units/ml oral suspension?

Nystatin 100 000 U/mL Oral Suspension

(brand name: Mycostatin®, Natacyn®, etc.)

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1. What is it?

• Drug class: Polyene antifungal
• Mechanism: Binds to ergosterol in fungal cell membranes, creating pores that increase permeability and cause cell death.

2. Primary Indications

• Oral candidiasis (thrush) in children and adults
• Fungal infections of the mouth and pharynx
• Topical treatment for some cutaneous infections (not the oral suspension)

(Note: It is not an antifungal for systemic infections.)

3. Typical Adult Dosage (Oral Suspension)

Age	Dose	Frequency	Notes
Adults & Children >12 mo	5 mL (≈ 500 000 U)	3–4×/day	Swish in mouth, then swallow.
Children 6–12 mo	2.5 mL (≈ 250 000 U)	3–4×/day	Adjust according to weight.

Course length: 7–14 days (extend if symptoms persist).
Tolerability: Mild GI upset is common; advise patient to avoid eating/drinking 30 min before next dose.

⚠️ Do not exceed the labeled dose; the suspension is not intended for intravenous or systemic use.

4. Common Adverse Effects

Symptom	Frequency
Nausea, vomiting, diarrhea	< 5 %
Oral irritation/itching	~ 2–4 %
Mild allergic reaction (rash, pruritus)	< 1 %

Severe hypersensitivity (anaphylaxis) is very rare but requires immediate medical care.

5. Contraindications

• Known hypersensitivity to nystatin or any component of the suspension
• Severe hepatic impairment (rarely relevant for oral use but noted in prescribing info)

6. Drug Interactions

• Minimal systemic absorption → few systemic interactions.
• Topical interactions: No significant interactions with oral medications.
• Caution with other topical antifungals: concurrent use may increase local irritation.

7. Special Populations

Population	Considerations
Pregnancy/Breastfeeding	Generally considered safe; still consult healthcare provider.
Renal impairment	No dose adjustment needed.
Pediatrics (<6 mo)	Not recommended; limited data.

8. Patient Counseling Points

• How to use: Shake well. Measure the dose with a measuring cup or syringe. Swish for 30–60 s before swallowing.
• Avoid food/drink for 30 min after each dose to maximize contact.
• Finish the course even if symptoms improve earlier to prevent recurrence.
• Watch for signs of an allergic reaction (rash, swelling, difficulty breathing). Seek medical help if they occur.
• Do not share medication with others.

9. Storage & Handling

• Store at 20–25 °C (room temperature).
• Keep the bottle tightly closed and out of direct sunlight.
• Discard after 6 months from the first opening (check the label for specific shelf‑life).

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Quick FAQ

Question	Answer
Can it be used for skin fungal infections?	The oral suspension is meant for mouth/thrush. For skin, use an over‑the‑counter nystatin cream or other topical antifungals.
What if I miss a dose?	Take it as soon as you remember. If it’s almost time for the next dose, skip the missed one and resume the regular schedule. Do not double‑dose.
Will it kill gut flora?	Very little systemic absorption; minimal impact on gut flora.
Is it safe with other antifungals?	Generally safe; however, using multiple antifungals may increase local irritation.

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Disclaimer:
This information is for educational purposes only and does not replace individualized medical advice. If you have questions about your specific health condition, dosage, or potential interactions, consult your prescribing clinician or pharmacist.