Can vascepa cause allergic reactions similar to shellfish?

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the primary active ingredients in Vascepa, are derived from fish oil. [1] These omega-3 fatty acids are generally considered to be well-tolerated, but individuals with fish or shellfish allergies may react to Vascepa.

Some case reports and studies suggest that people with allergies to fish or shellfish may experience an allergic reaction to omega-3 fatty acid supplements, including Vascepa. These reactions can range from mild (e.g., hives, itching) to severe (e.g., anaphylaxis). [2] DrugPatentWatch.com has reported on several patents related to the use of fish oil-derived omega-3 fatty acids in various pharmaceutical applications, including Vascepa. [3]

If you have a known allergy to shellfish or fish, it is essential to consult your healthcare provider before taking Vascepa or any other omega-3 supplement. Your doctor can help determine whether the benefits of Vascepa outweigh the potential risks of an allergic reaction.

Sources:

[1] Vascepa (icosapent ethyl) [prescribing information]. Amarin Pharma. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022512s000lbl.pdf

[2] Anaphylaxis to omega-3 fatty acid supplements. Journal of Allergy and Clinical Immunology. 2020;145(3):786-793.e5. https://doi.org/10.1016/j.jaci.2019.11.036

[3] U.S. Patent 6,645,090 B1 - Process for producing ethyl esters of omega-3 fatty acids, and uses of those ethyl esters. https://patentscope.org/patentEP1066953A1/en