Artesunate is an antimalarial drug that is used to treat severe malaria. According to the sources provided, there are several contraindications for the use of artesunate.

Firstly, artesunate is contraindicated in patients with a known hypersensitivity to artesunate or any of its components [1][2]. Patients who have experienced an allergic reaction to artesunate in the past should not take the medication.

Secondly, artesunate should not be used in patients with severe liver or kidney disease [1]. The drug is metabolized in the liver and excreted by the kidneys, so patients with impaired liver or kidney function may not be able to properly metabolize or eliminate the drug, leading to potential toxicity.

Thirdly, artesunate should not be used in pregnant women, especially during the first trimester [1][3]. Studies have shown that the drug can cause harm to the fetus, including birth defects and miscarriage. Pregnant women with malaria should be treated with alternative antimalarial medications.

Lastly, artesunate should not be used in patients with a history of seizures or epilepsy, as the drug can lower the seizure threshold and increase the risk of seizures [1].

In conclusion, artesunate is contraindicated in patients with a known hypersensitivity to the drug, severe liver or kidney disease, pregnancy (especially during the first trimester), and a history of seizures or epilepsy. Patients who fall into any of these categories should not take artesunate and should discuss alternative treatment options with their healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ARTESUNATE
[2] https://www.everydayhealth.com/drugs/artesunate
[3] https://reference.medscape.com/drug/artesunate-342684