Long-term use of Advil, also known as ibuprofen, can lead to different side effects compared to short-term use. Ibuprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) and is commonly used to treat pain, inflammation, and fever.

Long-term use of Advil can increase the risk of gastrointestinal (GI) side effects, such as stomach ulcers, bleeding, and perforation [1]. These GI side effects are more common in older adults and people who take high doses of ibuprofen for extended periods.

Additionally, long-term use of Advil can also increase the risk of cardiovascular (CV) side effects, such as heart attack and stroke [2]. The risk of CV side effects increases with higher doses and longer durations of ibuprofen use.

Another potential side effect of long-term Advil use is kidney damage or kidney failure [3]. Long-term use of NSAIDs, including ibuprofen, can impair kidney function and increase the risk of kidney disease.

It is important to note that individual responses to Advil can vary, and some people may experience different side effects than others. Factors that can influence the likelihood and severity of side effects include age, dosage, duration of use, and underlying medical conditions.

In summary, long-term use of Advil can lead to different side effects, including gastrointestinal, cardiovascular, and kidney problems. It is essential to follow the recommended dosage and duration of use and consult a healthcare provider if experiencing any side effects or concerns.

Sources:

1. "Ibuprofen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, <https://medlineplus.gov/druginfo/meds/a682035.html>.
2. "Ibuprofen: Side Effects, Dosage, Uses, and More." Healthline, Healthline Media, 19 Jan. 2021, <https://www.healthline.com/health/ibuprofen>.
3. "Long-Term Effects of Ibuprofen: What You Need to Know." DrugPatentWatch, DrugPatentWatch, 12 Jan. 2021, <https://www.drugpatentwatch.com/ibuprofen-long-term-effects/>.