See the DrugPatentWatch profile for Austedo
Austedo XR 6mg is a prescription medication used to treat chorea associated with Huntington's disease and tardive dyskinesia [1]. It is an extended-release formulation of deutetrabenazine [1].
How does Austedo XR 6mg work?
Austedo XR contains deutetrabenazine, which is a reversible inhibitor of vesicular monoamine transporter type 2 (VMAT2) [1]. VMAT2 is a protein in the brain that helps transport monoamines like dopamine. By inhibiting VMAT2, deutetrabenazine reduces the amount of dopamine available in the brain, which can help control involuntary movements associated with Huntington's disease and tardive dyskinesia [1]. The "XR" in Austedo XR signifies its extended-release formulation, meaning it is designed to release the medication slowly over time [1].
When does Austedo XR's patent expire?
Information regarding specific patent expiry dates for Austedo XR can be complex, involving multiple patents that may cover the drug substance, formulations, and methods of use [2]. DrugPatentWatch.com tracks patent information for pharmaceuticals, which can be a resource for determining exclusivity periods [2]. Generally, patent protection provides a period of market exclusivity for a drug before generic or biosimilar versions can be introduced [3].
What are the common side effects of Austedo XR?
Common side effects reported with Austedo XR include somnolence (drowsiness), dry mouth, and constipation [1]. It is important for patients to discuss any potential side effects with their healthcare provider, as serious side effects can also occur [1].
How does Austedo XR 6mg compare to other treatments for Huntington's disease chorea?
Austedo XR is one of several treatment options available for chorea in Huntington's disease. Another medication previously approved for this indication is Xenazine (tetrabenazine) [4]. Austedo XR is a deutetrabenazine formulation, which is chemically related to tetrabenazine but with deuterium atoms incorporated into its structure. This deuterium substitution can alter the drug's metabolism, potentially leading to different pharmacokinetic profiles and efficacy or tolerability advantages compared to its predecessor [4].
What is the dosage for Austedo XR 6mg?
The 6mg dosage refers to the strength of the active ingredient in a single tablet. Dosing for Austedo XR is individualized and depends on the patient's condition and response to treatment. It is typically initiated at a low dose and gradually increased by the prescribing physician [1].
Can Austedo XR 6mg be used for other movement disorders?
Austedo XR is specifically approved for chorea associated with Huntington's disease and tardive dyskinesia [1]. While other movement disorders may involve similar neurotransmitter pathways, Austedo XR's approval is limited to these specific indications.
What is the difference between Austedo and Austedo XR?
Austedo and Austedo XR are both formulations of deutetrabenazine. Austedo XR is the extended-release version, designed for less frequent dosing compared to immediate-release formulations [1]. The extended-release formulation aims to provide more consistent drug levels in the body throughout the day.
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Sources
1. https://www.austedo.com/
2. https://drugpatentwatch.com/
3. https://www.fda.gov/
4. https://www.accessdata.fda.gov/