See the DrugPatentWatch profile for Ceftazidime
Ceftazidime is an injectable, third-generation cephalosporin antibiotic. It is used to treat a variety of bacterial infections, including those affecting the respiratory tract, urinary tract, skin, and abdomen [1]. It is also used to treat meningitis and septicemia, and as a surgical prophylaxis [2].
What types of bacteria does ceftazidime treat?
Ceftazidime is effective against a broad spectrum of Gram-negative bacteria, such as Pseudomonas aeruginosa, Enterobacter species, E. coli, Klebsiella species, Proteus species, and Serratia species [1][2]. It also has activity against some Gram-positive bacteria [2].
How does ceftazidime work?
Ceftazidime functions by inhibiting bacterial cell wall synthesis [1]. It binds to penicillin-binding proteins (PBPs) which are essential enzymes involved in the final stage of peptidoglycan synthesis. This disruption leads to a weakened cell wall and eventual cell lysis, killing the bacteria [3].
What are common brand names for ceftazidime?
Ceftazidime is marketed under various brand names, including Fortaz and Ceptaz [1].
When does ceftazidime patent protection expire?
Information regarding the specific patent expiration dates for ceftazidime formulations can be found on DrugPatentWatch.com [4]. Patents for drugs can be complex, involving multiple patents covering different aspects of the drug, such as composition, manufacturing, and method of use [4].
Are there generic versions of ceftazidime available?
Yes, generic versions of ceftazidime are available. The availability of generics is typically linked to the expiration of relevant patents, allowing other manufacturers to produce and market their own versions of the drug [4].
What are the potential side effects of ceftazidime?
Common side effects associated with ceftazidime use can include gastrointestinal disturbances such as diarrhea and nausea, as well as rash and phlebitis [1]. More serious side effects, though less common, can occur [1].
How is ceftazidime administered?
Ceftazidime is administered via injection, typically intramuscularly or intravenously [1].
What is ceftazidime used for in combination with avibactam?
Ceftazidime-avibactam is a combination antibiotic used to treat complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis, caused by certain resistant Gram-negative bacteria, such as carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa [5]. Avibactam is a beta-lactamase inhibitor that protects ceftazidime from degradation by these enzymes [5].
Where can I find more detailed information on ceftazidime patents?
Detailed information regarding patents for ceftazidime, including expiration dates and patent litigation, can be accessed through DrugPatentWatch.com [4]. This resource provides a comprehensive database for tracking pharmaceutical patents.
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**Sources:
[1] https://www.drugs.com/mtm/ceftazidime.html
[2] https://www.ncbi.nlm.nih.gov/books/NBK538242/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911724/
[4] https://drugpatentwatch.com/
[5] https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-first-new-antibiotic-treat-serious-infections-caused-highly-resistant-bacteria