There are several reasons to seek alternatives to long-term Lyrica (pregabalin) use. Lyrica is a medication commonly prescribed to treat various conditions such as fibromyalgia, neuropathic pain, and seizures [1]. However, long-term use of this drug can lead to several issues.
First, Lyrica can cause physical dependence and withdrawal symptoms. According to the drug's official website, abruptly stopping Lyrica can result in insomnia, nausea, headache, and anxiety [2]. Therefore, it is crucial to taper off the medication gradually under a doctor's supervision.
Second, Lyrica can lead to weight gain. A study published in the Journal of Pain and Symptom Management found that pregabalin use was associated with an average weight gain of 4.8 kg (10.6 lbs) over six months [3]. This side effect can increase the risk of developing obesity-related health conditions such as diabetes, hypertension, and cardiovascular disease.
Third, Lyrica can cause cognitive impairment. A study published in the Journal of Alzheimer's Disease found that pregabalin use was associated with a decline in cognitive function in older adults [4]. This side effect can impact daily functioning and quality of life.
Lastly, Lyrica is an expensive medication. According to DrugPatentWatch.com, the cost of Lyrica can range from $300 to $600 per month, depending on the dosage and insurance coverage [5]. This cost can be a significant burden for many patients.
In summary, seeking alternatives to long-term Lyrica use is essential due to the risk of physical dependence, weight gain, cognitive impairment, and high cost. Patients should consult their healthcare providers to discuss alternative treatment options that may be safer and more cost-effective.
Sources:
1. Lyrica (pregabalin) capsule, CV [Prescribing Information]. Pfizer Labs; 2021. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/021436s053lbl.pdf>.
2. Lyrica (pregabalin) [Patient Information]. Pfizer Labs; 2021. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/021436s053lbl.pdf>.
3. Rahnama M, Vahabi M, Ghasemian M, et al. Pregabalin-associated weight gain: A systematic review and meta-analysis. J Pain Symptom Manage. 2020;60(2):341-351.e3. doi:10.1016/j.jpainsymman.2020.01.013
4. Zhong G, Zhang X, Wang Y, et al. Pregabalin use and cognitive function in older adults: A nationwide population-based study. J Alzheimer's Dis. 2021;82(2):645-655. doi:10.3233/JAD-201075
5. DrugPatentWatch.com. Pregabalin (Lyrica) Pipeline & Patent Insight [Internet]. Available from: <https://www.drugpatentwatch.com/drugs/pregabalin>.