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Why the pill shape and coating matter Lipitor tablets have a protective film coating that keeps the drug stable until it reaches the stomach. Crushing or splitting the tablet breaks this coating and can change how much atorvastatin your body absorbs at once. Can you split the tablet instead? The 10 mg, 20 mg, and 40 mg strengths have a score line and are approved for splitting. The 80 mg tablet is not scored and should not be divided. What happens if you crush it anyway? - The drug may dissolve too fast, raising peak blood levels and the chance of muscle pain or liver enzyme changes. - Taste becomes unpleasant and the powder sticks to teeth or the mouth. How pharmacists usually handle it If swallowing is difficult, they can switch you to the generic oral suspension or to a different statin that comes in a liquid or chewable form. Always check with the pharmacist before altering any tablet. Patent and generic availability Atorvastatin’s original U.S. patent expired in 2011, so multiple generics are sold. Tablet splitting remains acceptable for scored strengths even after generic entry.
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