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Here’s the usual quick rule for hydromorphone (Dilaudid): - IV to PO conversion (approximate): 1 mg IV = about 6 mg PO. - So PO dose ≈ IV dose × 6. Examples: - 2 mg IV → ~12 mg PO - 4 mg IV → ~24 mg PO Important safety notes: - This is an approximate conversion. Individual factors (tolerance, liver/renal function, formulation, onset of action) can change things. - Because of incomplete cross-tolerance when switching opioids, many clinicians start at a lower point and titrate. A common approach is to give about 50% of the calculated PO dose initially and adjust based on pain relief and side effects. - Different oral products exist (immediate-release vs extended-release). Use the same type (or convert appropriately) and avoid mismatches. - If the patient is opioid-naive, start even lower and proceed with caution. If you have a specific IV dose and the exact PO formulation (IR or ER) and whether the patient is opioid-tolerant, I can work out a more precise example.
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