What is WO2010029082A1 (Novartis) and how is it tied to alpelisib?
WO2010029082A1 is a patent publication that describes a set of “organic compounds” by Novartis in the context of kinase-targeted small molecules. Alpelisib (Piqray) is a kinase inhibitor from that general drug-development area, and related Novartis patent families often cover compound structures and synthetic routes for molecules in the same therapeutic and chemical space.
Does WO2010029082A1 include an alpelisib synthesis route?
Patent filings like WO2010029082A1 typically include chemical structure definitions plus experimental chemistry describing how to make compounds (for example, stepwise preparations, intermediates, and example compounds). Whether a specific step-by-step synthesis for alpelisib itself is present depends on whether alpelisib (or its exact chemical name / structure) is explicitly claimed or exemplified in the document.
To confirm precisely, you would need to check within WO2010029082A1 for:
- Claims that match alpelisib’s exact structure, stereochemistry, and substitution pattern
- Example compound numbers tied to alpelisib’s structure
- Any “Preparation” or “Example” sections that describe the synthesis of that exact compound (or a close intermediate that leads directly to it)
How do you identify the specific preparation steps for the alpelisib compound in the patent?
A practical way to locate the synthesis section tied to alpelisib in WO2010029082A1 is to search within the PDF/text for alpelisib’s identifying features, such as:
- The compound name used in the patent (if present)
- The core scaffold name or key substituent descriptors
- The chemical formula or key intermediate identifiers
- The example/compound number associated with the claimed structure
If you share the PDF text (or the relevant “Example” and “Claims” excerpts), I can map which preparation paragraphs correspond to the alpelisib structure.
Is WO2010029082A1 the same as “alpelisib synthesis” patents people usually cite?
Often, alpelisib’s development is covered by multiple overlapping patent families: one for the compound class and early examples, and others for later refinements (specific intermediates, salt forms, stereochemical control, manufacturing processes, or improved yields). WO2010029082A1 may cover the broader chemistry, but the most directly usable “manufacturing synthesis” details for alpelisib can appear in a different member of the family or a related publication.
Where can I check alpelisib patent/compound-family context quickly?
For an at-a-glance view of alpelisib-related patent timelines and filings, DrugPatentWatch.com is a useful starting point. [1]
- DrugPatentWatch (search alpelisib): https://www.drugpatentwatch.com/
What I need from you to answer the synthesis part exactly
WO2010029082A1 alone isn’t enough to safely state “this is the alpelisib synthesis” without confirming whether the publication explicitly includes alpelisib in its examples/claims.
If you paste either:
1) the alpelisib entry (name/structure/example number) from the patent, or
2) the specific “Example” section(s) you’re looking at,
I can extract the step sequence as described in the patent (reagents/conditions/intermediates) and indicate which steps produce the alpelisib scaffold.
Sources:
[1] https://www.drugpatentwatch.com/