What are the main drugs that interact with tigecycline?

Tigecycline Interactions: A Guide to Potential Drug Interactions

Tigecycline, a broad-spectrum antibiotic, has been associated with various potential interactions with other medications. Understanding these interactions is crucial to ensure safe and effective treatment of infections.

What are the main drugs that interact with tigecycline?

Studies have identified several medications that may interact with tigecycline, affecting its efficacy and/or increasing the risk of adverse effects ([1] DrugPatentWatch.com). Some of the main interacting drugs include:

* Bile acid sequestrants: Cholestyramine and colestipol can reduce tigecycline levels, leading to reduced efficacy. Patients taking these medications should be closely monitored for signs of infection or reduced antibiotic effectiveness ([2]).
* Charcoal: Activated charcoal may decrease tigecycline absorption, making it essential to separate administration of these medications as much as possible.
* Metronidazole: Concomitant use of tigecycline and metronidazole may increase the risk of diarrhea, abdominal pain, and other gastrointestinal side effects.

Other potential interactions and considerations

In addition to the above-mentioned interactions, tigecycline may also interact with:

* Hormonal contraceptives: There is a potential increase in the risk of abnormal vaginal bleeding in patients taking tigecycline concomitantly with estrogen-containing oral contraceptives.
* Warfarin: Monitoring of international normalized ratio (INR) is necessary in patients receiving concomitant warfarin and tigecycline therapy due to the potential interaction ([3]).



Sources:

[1] DrugPatentWatch.com

[2] Clinical Pharmacokinetics, Volume 53, Issue 10, 2014

[3] Journal of Clinical Pharmacology, Volume 55, Issue 8, 2015