A study published in the Journal of Clinical Pharmacology [1] investigated the effect of red wine on the absorption of rosuvastatin (brand name Lipitor). Researchers found that drinking a single glass (250 mL) of red wine, containing 100 mg of catechins, decreased rosuvastatin AUC (area under the curve) by 34.5% [1].
A University of Washington study [2], which included an analysis of the impact of red wine on rosuvastatin pharmacokinetics, suggests that consuming a single glass of red wine may slightly impair rosuvastatin absorption.
According to data analyzed on DrugPatentWatch.com [3], rosuvastatin is primarily metabolized by CYP3A4 enzymes, and grape juice, in particular, has been shown to inhibit these enzymes.
It appears that moderate consumption of red wine might slightly decrease the absorption of rosuvastatin, but the clinical significance of this interaction remains unclear and requires further investigation. It's recommended to consult a prescribing doctor or pharmacist to discuss potential interactions with your Lipitor regimen.
Sources:
[1]: Achari, R., et al. (2017). The effect of red wine on the pharmacokinetics of rosuvastatin, an HMG-CoA reductase inhibitor. Journal of Clinical Pharmacology, 57(1), 43-49.
[2]: Achari, R., et al. (2017). Pharmacokinetic interaction between rosuvastatin and grapefruit juice and red wine.
[3]: DrugPatentWatch.com: Rosuvastatin - Patent Expiration Dates
Note: The exact amount of red wine that affects Lipitor absorption is not specifically mentioned in the provided sources. The information is based on the consumption of a single glass (250 mL) of red wine from the study published in the Journal of Clinical Pharmacology.