Is mmr vaccine effectiveness changed by taking cosentyx?

Short answer: Yes, taking Cosentyx (secukinumab) can affect how well a measles/mumps/rubella (MMR) vaccine works, and the MMR vaccine (a live attenuated vaccine) is generally not recommended to be given while on cosentyx.

What this means in practice:
- MMR is a live vaccine. Live vaccines are usually avoided in people who are immunosuppressed or on biologic immune therapies because of safety concerns and possibly a poorer vaccine response.
- Secukinumab inhibits IL-17A and can dampen immune responses. That can reduce the body’s ability to mount a robust response to vaccines, including MMR.
- Because of these issues, most guidelines suggest not giving MMR to someone actively taking cosentyx. If you need MMR, it’s best planned before starting cosentyx, if possible.

What to do next:
- If you’re not immune to measles, mumps, or rubella and you’re about to start cosentyx, discuss getting the MMR vaccine before starting therapy with your rheumatologist or dermatologist.
- If you’re already on cosentyx, don’t stop the medication without medical advice. Talk to your prescriber about the risks and benefits of vaccination and whether any alternative plan (e.g., delaying vaccination, or vaccination at a time when immune status might be safer) is appropriate for you.
- In some cases, your doctor might recommend vaccinating household contacts and caregivers to reduce transmission risk, rather than vaccinating you while you’re on cosentyx.

If you want, tell me a bit more about your situation (Are you planning MMR? Are you currently on cosentyx? What condition are you treating?), and I can tailor the guidance and help you prepare questions for your clinician. Also, always rely on your healthcare provider’s advice for your specific situation.