Naproxen sodium is an NSAID (nonsteroidal anti-inflammatory drug) used to relieve pain and reduce inflammation. It’s the salt form of naproxen and is commonly sold over the counter (OTC) as 220 mg tablets (brand example: Aleve).
Key points
- What it’s for: short-term relief of minor aches and pains (headache, backache, muscle aches, menstrual cramps) and to reduce fever.
- How to take (typical OTC adult dosing):
- Take 1 tablet every 8–12 hours as needed.
- Do not exceed 3 tablets (660 mg) in 24 hours unless directed by a doctor.
- Take with a full glass of water. Can take with food or milk to reduce stomach upset.
- Who should be cautious:
- People with stomach ulcers or bleeding, kidney disease, liver disease, uncontrolled high blood pressure, heart failure, or certain heart/kidney conditions.
- Those who recently had or are at risk for a heart attack or stroke (NSAIDs carry some risk with long-term use).
- Should be avoided in the late third trimester of pregnancy; consult a clinician if you’re pregnant or planning pregnancy.
- Avoid mixing with other NSAIDs (e.g., ibuprofen, ketorolac) unless advised by a clinician.
- Interactions to watch for:
- Anticoagulants (blood thinners, like warfarin) and other NSAIDs can increase bleeding risk.
- Some blood pressure meds, diuretics, and methotrexate can interact or have reduced effectiveness.
- Alcohol can increase stomach irritation and bleeding risk.
- Possible side effects (common to watch for):
- Upset stomach, heartburn, nausea, diarrhea, dizziness.
- More serious but rarer: vomiting blood, black/tarry stools, chest pain, signs of kidney trouble (fatigue, swelling, changes in urination), severe allergic reactions.
- Special populations:
- Children: OTC naproxen is generally for adults and children 12 years and older; dosing for kids should be guided by a pediatrician.
- Older adults and people with kidney or GI history should use caution and consult a clinician before use.
If you want, tell me:
- Your age and any medical conditions (kidney disease, ulcers, heart disease, high blood pressure)?
- Any other medications you’re taking?
- How you plan to use it (pain type, duration, pregnancy status)?
I can tailor dosing guidance, safety notes, and potential alternatives.