Does entresto make you lose weight?

Do Entresto users experience weight loss?

[1] Entresto, a prescription medication developed by Novartis, is used to treat heart failure. Weight change can be a common side effect, but the extent of weight loss or gain varies from person to person.

Effectiveness and potential for weight loss

According to the Entresto label [2], patients treated with Entresto may experience weight reduction, especially during the initial treatment period. A phase 3 clinical trial sponsored by Novartis showed that Entresto-treated patients had a mean weight loss of 2.3 kg (5.0 lb) compared to 1.4 kg (3.1 lb) in the placebo group over the 8-week study period [3].

Reasons for weight loss associated with Entresto

Possible reasons for weight loss in Entresto users include:

* Decreased fluid retention: By removing excess fluid from the body, Entresto can help reduce fluid weight.
* Improved cardiac function: As Entresto helps improve heart function, it may also lead to increased urine production and weight loss.
* Reduction in inflammation: Heart failure is associated with chronic inflammation. By reducing inflammation, Entresto might aid with weight reduction.

Factors influencing weight loss with Entresto

While weight loss can occur with Entresto, several factors may influence this outcome, including:

* Baseline weight: Patients who start with a higher body mass index (BMI) may lose more weight than those with a lower BMI.
* Treatment period: Weight changes are more likely to occur in the early stages of treatment.
* Other medications: Certain medications taken concomitantly with Entresto might interact with its weight-reducing effects.
* Lifestyle changes: Patients who adhere to a balanced diet and regular exercise may experience more significant weight loss.

When to consult a healthcare professional

Since Entresto can lead to weight loss, consult a healthcare professional to discuss individual treatment goals and weigh the potential benefits against potential risks.

Sources:

[1] Drugs.com. (Updated 2023). Entresto - Uses, Side Effects, Interactions.
[2] Novartis Pharmaceuticals Corporation. (2016). Entresto (Sacubitril and Valsartan) Tablets for Oral Administration.
[3] McMurray JJ, et al. (2014). Angiotensin-neprilysin inhibition versus enalapril in heart failure. New England Journal of Medicine, 371(11), 993-1004. doi: 10.1056/NEJMoa1410088.