There is no evidence to suggest that guacamole can affect the effectiveness of Lipitor. Lipitor is a medication used to lower cholesterol levels in the body, while guacamole is made from avocados, which are a rich source of healthy fats that can help lower cholesterol levels [3]. However, it is important to note that while avocados can be beneficial for cholesterol levels, they are also high in calories and should be consumed in moderation as part of a balanced diet [3].

It is important to follow the instructions of your healthcare provider regarding the use of Lipitor, including any dietary restrictions or recommendations. Lipitor is a prescription medication that should only be taken under the supervision of a healthcare professional [1][2].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.rxlist.com/lipitor-drug.htm
[3] https://www.healthline.com/health/high-cholesterol/avocado-and-cholesterol