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See the DrugPatentWatch profile for Entresto
What is Entresto's mechanism of action? Entresto, also known as sacubitril/valsartan, is a medication used to treat heart failure. It works by combining two different mechanisms of action: 1. Neprilysin inhibition [1]: Sacubitril is a neprilysin inhibitor, which means it blocks the action of the enzyme neprilysin. Neprilysin breaks down certain naturally occurring peptides that help regulate blood pressure and fluid balance. By inhibiting neprilysin, Entresto increases the levels of these peptides, leading to improved blood pressure reduction and decreased fluid accumulation. 2. Angiotensin receptor blockade [2]: Valsartan is an angiotensin II receptor blocker (ARB), which blocks the action of angiotensin II, a potent vasoconstrictor. By blocking the angiotensin II receptor, valsartan decreases blood pressure and reduces the strain on the heart. Why was Entresto developed? Entresto was developed to address the limitations of traditional treatments for heart failure, such as ACE inhibitors and beta-blockers. These medications often have limited efficacy and are not sufficient to slow the progression of heart failure. Entresto offers a new approach by targeting two distinct pathways involved in heart failure, providing a more effective treatment option. What are the benefits of using Entresto? Studies have shown that Entresto significantly reduces the risk of cardiovascular death and hospitalization in patients with heart failure. Entresto also improves patient outcomes, including reduced symptoms, improved quality of life, and increased survival rates [3]. When was Entresto approved and for how long? Entresto was approved by the FDA in 2015 as a treatment for heart failure in patients with left ventricular ejection fraction (LVEF) ≤ e40% or with a history of hospitalization for heart failure [4]. Entresto's approval is set to expire in 2026. Patent expiration According to PatentWatch [5], Entresto's patent expires in 2031, allowing biosimilar manufacturers to enter the market. Sources: [1] DrugPatentWatch.com [2] FDA.gov [3] NEJM.org [4] ClinicalTrials.gov [5] DrugPatentWatch.com
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