Does Vyvanse Cause Headaches?
Yes, headaches are a common side effect of Vyvanse (lisdexamfetamine), a stimulant used for ADHD and binge eating disorder. Clinical trials and post-marketing reports list headaches in 8-26% of patients, depending on the study and dose.[1][2]
How Common Are Headaches on Vyvanse?
In pivotal trials for ADHD:
- Children (6-12 years): Up to 13% reported headaches vs. 10% on placebo.
- Adolescents: 12% vs. 7% placebo.
- Adults: 26% vs. 8% placebo.
Headaches often start early in treatment and may decrease over time, but they affect more users on Vyvanse than placebo.[2][3]
Why Do Headaches Happen?
Vyvanse increases dopamine and norepinephrine, raising blood pressure and constricting blood vessels, which can trigger vascular headaches or migraines. Dehydration from appetite suppression worsens this. Higher doses (50-70 mg) correlate with more reports.[1][4]
How Long Do They Last?
Most headaches are mild and resolve within days to weeks as the body adjusts. If persistent beyond 1-2 weeks or severe, they signal issues like high blood pressure or tolerance buildup.[2][5]
What If Headaches Don't Go Away?
Consult a doctor—could indicate overdose, interactions (e.g., with SSRIs), or conditions like hypertension. Dose reduction, hydration, or switching meds helps 70-80% of cases. Migraine meds like sumatriptan are sometimes added, but avoid with stimulants due to serotonin risks.[3][6]
Compared to Adderall or Other ADHD Meds
Vyvanse causes similar headache rates to Adderall XR (20-25%), but fewer than immediate-release amphetamines. Non-stimulants like Strattera have lower rates (10-15%). Patients switching from Adderall report no big difference in headaches.[4][7]
Tips to Reduce Headaches