Aspirin is a widely used medication for pain relief and to prevent heart attacks and strokes. However, it can also cause side effects, such as stomach bleeding, particularly when taken in high doses. According to the Mayo Clinic [3], the recommended daily dose of aspirin for most people is between 81 and 325 milligrams. This low dose is usually safe and effective in preventing blood clots that can lead to heart attacks and strokes. However, taking higher doses of aspirin can increase the risk of stomach bleeding.

A study published in the American Journal of Medicine [2] found that the risk of stomach bleeding increased significantly in people taking more than 300 milligrams of aspirin per day. The risk was highest in people taking more than 1,200 milligrams of aspirin per day. The study also found that the risk of stomach bleeding was higher in older people, people with a history of stomach ulcers, and people taking other medications that can increase the risk of bleeding.

Drug Patent Watch [1] indicates that aspirin is available in various dosages, ranging from 81 milligrams to 500 milligrams. However, it is important to note that the dosage of aspirin that increases the risk of stomach bleeding can vary depending on individual factors, such as age, medical history, and other medications being taken. Therefore, it is important to consult with a healthcare provider before taking aspirin or any other medication.

In conclusion, taking high doses of aspirin, particularly more than 300 milligrams per day, can increase the risk of stomach bleeding. However, the recommended daily dose of aspirin for most people is between 81 and 325 milligrams [3]. It is important to consult with a healthcare provider before taking aspirin or any other medication to determine the appropriate dosage and to discuss potential risks and benefits.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086018/
[3] https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin-therapy/art-20046797