Bupropion hcl dosage?

Bupropion hydrochloride dosing depends on the product formulation and the purpose (depression vs. smoking cessation). Here are typical adult dosing ranges. Always follow your clinician’s instructions and the product label.

- Immediate-release (IR) bupropion hcl
- Typical use: depression (MDD)
- Dose: 100 mg 2–3 times daily (at least 6 hours apart)
- Usual max: 450 mg/day (e.g., 150 mg 3 times daily)
- Notes: start lower and titrate; do not exceed the max

- Sustained-release (SR) bupropion hcl
- Typical use: depression (MDD)
- Dose: 150 mg twice daily (morning and afternoon, at least 8 hours apart)
- Usual max: 400 mg/day (e.g., 200 mg twice daily)
- Notes: after 3–7 days, may increase if tolerated

- Extended-release (XL) bupropion hcl
- Typical use: depression (MDD)
- Dose: start 150 mg once daily for 3 days, then 300 mg once daily
- Usual max: 450 mg/day
- Notes: take in the morning to reduce insomnia

- Bupropion for smoking cessation (Zyban; usually SR)
- Dose: 150 mg once daily for 3 days, then 150 mg twice daily
- Typical total daily dose: 300 mg/day
- Duration: often 7–12 weeks; start 1–2 weeks before quit date (per product label)
- Max: 300 mg/day

Important safety reminders
- Risk of seizures is higher at higher doses; not for people with a history of seizures, bulimia/anorexia, or certain other conditions.
- Do not use with MAOI inhibitors or certain other medications unless directed by a clinician.
- Take XL in the morning (to reduce insomnia); SR/IR dosing is divided throughout the day.
- Do not crush or chew extended-release or sustained-release tablets.

If you tell me which formulation and indication you’re asking about (depression vs smoking cessation), I can tailor the dosing details more precisely. Also, if you have any medical conditions or other meds, share them and I can review for potential interactions.