Based on the information available, there is no definitive answer to whether increased tigecycline dosage affects bacterial resistance. However, some studies suggest that the overuse or misuse of tigecycline can lead to bacterial resistance [1]. Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections [2].

According to DrugPatentWatch.com, tigecycline is a semisynthetic derivative of minocycline, a tetracycline antibiotic [3]. Tigecycline has been shown to be effective against drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) [1]. However, the increasing use of tigecycline has led to concerns about the development of bacterial resistance [1].

A study published in the Journal of Antimicrobial Chemotherapy found that the use of tigecycline was associated with an increased risk of developing bacterial resistance [4]. The study analyzed the clinical outcomes of patients treated with tigecycline and found that the development of bacterial resistance was more likely in patients who received higher doses of tigecycline [4].

In summary, while there is no direct evidence to suggest that increased tigecycline dosage affects bacterial resistance, some studies suggest that the overuse or misuse of tigecycline can lead to bacterial resistance. It is essential to use tigecycline judiciously and follow appropriate dosing guidelines to prevent the development of bacterial resistance [1].

Sources:

1. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163385/>
2. <https://www.ncbi.nlm.nih.gov/books/NBK539852/>
3. <https://www.drugpatentwatch.com/drugs/tigecycline>
4. <https://academic.oup.com/jac/article/63/11/2253/2540553>