After reviewing the available information, it appears that there is some evidence to suggest that prolonged use of tigecycline, an antibiotic, may be associated with an increased risk of liver enzyme elevation.

According to a study published in the Journal of Clinical Pharmacy and Therapeutics, tigecycline has been associated with elevations in liver function tests, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) [3]. The study found that the incidence of liver enzyme elevations was higher in patients who received tigecycline for longer durations, suggesting a possible link between prolonged use and liver enzyme abnormalities.

Furthermore, the drug label for tigecycline, available on DrugPatentWatch, includes a warning about the potential for liver enzyme elevations, particularly in patients who receive the drug for prolonged periods [1].

However, it is important to note that liver enzyme elevations can occur for a variety of reasons, and not all cases are necessarily caused by tigecycline. A review of the literature published in the Journal of Medical Toxicology found that liver enzyme elevations are a common occurrence in hospitalized patients, and that it can be challenging to determine the specific cause of these elevations [2].

In summary, while there is some evidence to suggest that prolonged use of tigecycline may be associated with an increased risk of liver enzyme elevation, more research is needed to fully understand the nature of this relationship. Healthcare providers should monitor liver function tests in patients receiving tigecycline, particularly those receiving the drug for prolonged periods.

Sources:

1. <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
2. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594628/>
3. <https://pubmed.ncbi.nlm.nih.gov/25547356/>