See the DrugPatentWatch profile for Dupixent
Dupixent is manufactured by Regeneron Pharmaceuticals [1]. Regeneron jointly develops and markets Dupixent with Sanofi [2].
How does Dupixent work?
Dupixent, also known by its generic name dupilumab, is a monoclonal antibody that works by blocking the activity of specific proteins called interleukin-4 (IL-4) and interleukin-13 (IL-13) [3]. These proteins are involved in the inflammatory pathways of certain allergic and atopic conditions [3]. By inhibiting IL-4 and IL-13, Dupixent helps to reduce inflammation, which can alleviate symptoms associated with these diseases [3].
What conditions does Dupixent treat?
Dupixent is approved for the treatment of several inflammatory conditions [4]. These include moderate-to-severe atopic dermatitis in adults and children, moderate-to-severe asthma in adults and children, and chronic rhinosinusitis with nasal polyps in adults [4]. It is also indicated for eosinophilic esophagitis in adults and children aged 12 years and older, and for prurigo nodularis in adults [4]. The specific age ranges and severity criteria for each indication may vary [4].
When does Dupixent's patent expire?
Information regarding the specific patent expiry dates for Dupixent is available through patent tracking resources. DrugPatentWatch.com tracks patent information for many pharmaceuticals, including Dupixent [5]. Patent expiry dates are crucial for determining when generic versions of a drug may become available [5].
Who are Dupixent's main competitors?
The competitive landscape for Dupixent includes other biologic medications and traditional therapies used to treat the same conditions. For atopic dermatitis, competitors include other JAK inhibitors and topical corticosteroids. In asthma, Dupixent competes with other biologics targeting different inflammatory pathways, such as those targeting IgE or IL-5 [4]. The specific competitors can vary depending on the approved indication [4].
What is the cost of Dupixent?
The cost of Dupixent can be substantial, as is common with many biologic medications [6]. Pricing varies by geographic region, insurance coverage, and pharmacy [6]. Patients may have access to co-pay assistance programs offered by the manufacturer to help manage out-of-pocket expenses [6].
What are the potential side effects of Dupixent?
Common side effects associated with Dupixent include injection site reactions, such as redness, itching, and swelling [7]. Other reported side effects can involve inflammation of the eye, such as conjunctivitis or keratitis, and oral herpes [7]. Patients should discuss any potential side effects with their healthcare provider [7].
Sources:
[1] https://www.regeneron.com/
[2] https://www.sanofi.com/
[3] https://www.dupixent.com/
[4] https://www.dupixent.com/about-dupixent/conditions
[5] https://drugpatentwatch.com/
[6] https://www.dupixent.com/cost-and-insurance
[7] https://www.dupixent.com/side-effects