List of dopamine antagonist drugs?

What are dopamine antagonist drugs?

Dopamine antagonists are medications that block dopamine receptors. They’re used for conditions such as psychosis, nausea/vomiting (especially via D2 blockade in the brain and GI tract), and other disorders depending on which dopamine receptor subtype they target.

Which dopamine antagonist drugs are commonly used?

Common dopamine antagonist medications include:

- Antipsychotics (D2 antagonists)
- Haloperidol
- Chlorpromazine
- Fluphenazine
- Thioridazine
- Perphenazine
- Trifluoperazine
- Pimozide
- Risperidone
- Paliperidone
- Olanzapine
- Quetiapine
- Clozapine
- Ziprasidone
- Lurasidone
- Brexpiprazole (partial agonist at dopamine receptors, but often discussed in the same therapeutic group as dopamine-modulating antipsychotics)

- Antiemetics (anti-nausea/vomiting; typically D2 antagonists)
- Metoclopramide
- Domperidone
- Prochlorperazine
- Promethazine
- Trimethobenzamide (dopamine-receptor related antiemetic)
- Droperidol

Are all antipsychotics “dopamine antagonists”?

Most antipsychotics have strong dopamine-receptor activity, but not all are pure antagonists. Some are partial agonists or have different receptor profiles (serotonin and dopamine). If you need a strict list limited to drugs that act primarily as dopamine receptor antagonists (especially D2), tell me which receptor subtype you mean (D2 vs others).

Want the list by purpose (psychosis vs nausea) or by receptor subtype (D2 vs D3/D4)?

If you tell me your use case (study list, clinical list for nausea, or a strict D2-antagonist-only list), I can format the drugs accordingly.