Does Jardiance Cause Low Blood Pressure?
Yes, Jardiance (empagliflozin) can cause low blood pressure, known medically as hypotension. This occurs because the drug promotes fluid loss through urination, which reduces blood volume and can lower blood pressure. Clinical trials and post-marketing reports confirm this side effect, with rates around 0.5-1% in studies, though it's more common in patients already on diuretics or with dehydration.[1][2]
Who Is Most at Risk?
Patients over 65, those with low BMI, or anyone on blood pressure-lowering drugs like diuretics or ACE inhibitors face higher risks. Dehydration from illness, excessive exercise, or low-salt diets can worsen it. Symptoms include dizziness, lightheadedness, fainting, or blurred vision—stop the drug and seek medical help if severe.[1][3]
How Common Is It Compared to Other SGLT2 Inhibitors?
Jardiance has a similar hypotension risk to other SGLT2 inhibitors like Farxiga (dapagliflozin) or Invokana (canagliflozin), but rates vary slightly by study population. In heart failure trials, empagliflozin showed hypotension in about 1-2% of users versus placebo.[2][4] It's less frequent than with loop diuretics but still requires monitoring.
What Do Doctors Recommend to Manage It?
Start with a low dose (10 mg daily) and increase only if tolerated. Drink plenty of fluids, avoid hot weather or saunas, and check blood pressure regularly. Your doctor may adjust other meds or add salt if needed. Report symptoms promptly, as untreated low BP raises fall risks.[1][3]
When Does It Usually Happen?
Hypotension often appears within weeks of starting or dose increases, but it can occur anytime with triggers like volume loss. It typically resolves after hydration or dose adjustment.[2]
Sources
[1]: Jardiance Prescribing Information (FDA)
[2]: Empagliflozin Safety Data (NEJM EMPA-REG OUTCOME Trial)
[3]: Mayo Clinic - Jardiance Side Effects
[4]: FDA Adverse Event Reporting System (FAERS) for SGLT2 Inhibitors