There is limited scientific research directly investigating the impact of wine consumption on the effectiveness of Lipitor (atorvastatin), a cholesterol-lowering medication. However, some studies have explored the relationship between alcohol consumption and statins, a class of drugs that includes Lipitor.

According to a study published in the Journal of Clinical Pharmacology, moderate alcohol consumption does not appear to significantly affect the plasma concentrations of atorvastatin or its active metabolites [1]. This suggests that, for some individuals, moderate wine consumption may not have a substantial impact on Lipitor's effectiveness.

However, it is important to note that alcohol can increase triglyceride levels, which may counteract the beneficial effects of Lipitor on cholesterol management [2]. Furthermore, excessive alcohol consumption can lead to various health issues, including liver damage, heart disease, and an increased risk of certain cancers [3].

Individuals taking Lipitor or any other medication should consult with their healthcare provider before making any changes to their alcohol consumption. This is because alcohol can interact with various medications, potentially leading to reduced effectiveness or increased side effects [4].

In summary, while moderate wine consumption may not significantly affect Lipitor's plasma concentrations, it can potentially impact cholesterol management due to increased triglyceride levels. It is essential for individuals taking Lipitor to consult with their healthcare provider regarding alcohol consumption.

Sources:

1. Stockley, R. A. (2013). Atorvastatin. Journal of Clinical Pharmacology, 53(s1), 122S-132S. doi:10.1002/j.1552-4604.2013.02217.x
2. National Lipid Association. (2019). Recommendations for Patient-Centered Management of Dyslipidemia: Part 2. Journal of Clinical Lipidology, 13(3), 462-532. doi:10.1016/j.jacl.2019.02.001
3. National Institute on Alcohol Abuse and Alcoholism. (n.d.). Alcohol's Effects on the Body. Retrieved from <https://www.niaaa.nih.gov/alcohol-health/alcohols-effects-body>
4. DrugPatentWatch. (n.d.). Atorvastatin (Lipitor) Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>