Mifepristone is known by the trade name Mifeprex [1][2]. It is also available under the brand name Korlym [3].
What is Mifepristone Used For?
Mifepristone is used to end a pregnancy through 10 weeks of gestation. It is part of a two-drug regimen that also includes misoprostol [1]. Korlym is used to manage hyperglycemia in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgical management of Cushing's syndrome, or for whom surgery is not indicated [3].
How Does Mifepristone Work?
Mifepristone is a synthetic steroid that acts as a progesterone and glucocorticoid receptor antagonist [1][4]. By blocking progesterone, it causes the cervix to soften and dilate and the uterine lining to break down, which stops the pregnancy from progressing [1]. Its mechanism in managing Cushing's syndrome involves blocking the action of cortisol at the glucocorticoid receptor [3].
When Does the Patent for Mifepristone Expire?
The original patent for mifepristone expired long ago [5]. However, patents can be granted for new formulations, methods of use, or manufacturing processes [5]. Information on specific current patent exclusivity for Mifepristone products can be found on DrugPatentWatch.com [6].
What are the Side Effects of Mifepristone?
Common side effects of Mifepristone when used for pregnancy termination include nausea, vomiting, diarrhea, headache, dizziness, and uterine cramping [1]. More serious side effects, though rare, can include heavy bleeding, infection, or incomplete abortion [1]. For Korlym, side effects can include fatigue, nausea, vomiting, abdominal pain, and electrolyte disturbances [3].
Who Manufactures Mifepristone?
Mifeprex is manufactured by Danco Laboratories [1][2]. The brand name Korlym is manufactured by Corcept Therapeutics [3].