What side effects can Humira (adalimumab) cause?
Humira can cause both common side effects and more serious reactions. Reported effects include reactions at the injection site and increased risk of infections, because the medicine suppresses parts of the immune system. [1][2]
What are the common side effects?
Commonly reported side effects include:
- Injection-site reactions (redness, itching, pain, swelling) [1]
- Headache [1]
- Rash [1]
- Upper respiratory symptoms (such as sore throat or runny nose) [2]
What serious side effects should people watch for?
Seek medical care promptly for signs of serious infections or other urgent reactions, including:
- Serious infections (for example, fever, persistent cough, weakness, or symptoms that rapidly worsen) [1][2]
- Tuberculosis (TB) or reactivation of TB symptoms (such as persistent cough, weight loss, night sweats) [2]
- Severe allergic reactions (such as trouble breathing, swelling of the face or throat, or hives) [1]
- Signs of liver problems (yellow skin/eyes, dark urine, severe fatigue) [1]
Does Humira increase the risk of infections?
Yes. Humira is a tumor necrosis factor (TNF) blocker, which can increase the risk of infections and may allow latent infections (including TB) to become active again. [1][2]
What about cancer and other long-term risks?
TNF blockers have been associated with certain malignancies and other immune-related conditions. Your clinician will weigh these risks against your diagnosis and disease severity. [2]
Pregnancy, breastfeeding, and side-effect concerns
If you are pregnant or breastfeeding, side effects and immune-related risks are important to discuss with your prescriber so treatment decisions can be individualized. [2]
When should you contact a doctor urgently?
Contact a clinician or seek urgent care if you develop symptoms that could indicate a serious infection (fever, shortness of breath, severe fatigue, persistent/worsening cough) or signs of an allergic reaction (trouble breathing, facial/throat swelling). [1][2]
How to reduce injection-related side effects
Injection-site discomfort is common. Using proper injection technique and rotating injection sites can help reduce local irritation, but persistent or severe reactions should be evaluated. [1]
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Sources
[1] https://www.rxlist.com/humira-side-effects-drug-center.htm
[2] https://www.drugs.com/sfx/humira-side-effects.html