What stomach symptoms are associated with prednisone use?
Prednisone, a corticosteroid medication, is known to cause various gastrointestinal side effects [1]. Stomach pain and discomfort are among the common complaints reported by patients taking prednisone. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), stomach upset, nausea, and vomiting are possible side effects of corticosteroids like prednisone [2].
Why does prednisone cause stomach pain?
The stomach pain associated with prednisone use can be attributed to several factors. Prednisone can alter the gastrointestinal tract's motility and sensitivity, leading to stomach cramps, bloating, and discomfort [3]. Additionally, prednisone can cause changes in the gut microbiome, which may contribute to gastrointestinal symptoms [4].
How common is stomach pain with prednisone use?
The frequency and severity of stomach pain caused by prednisone vary from person to person. A study published in the Journal of Clinical Gastroenterology reported that approximately 20-30% of patients taking corticosteroids experience gastrointestinal symptoms, including stomach pain [5].
Can stomach pain be managed while taking prednisone?
Fortunately, stomach pain associated with prednisone use can often be managed with over-the-counter antacids or acid reducers, such as Tums or Zantac [6]. Patients should discuss their symptoms with their healthcare provider to determine the best course of action. In some cases, prescribing medications that reduce stomach acid or alter gut motility may be necessary.
When should I consult my doctor about stomach pain?
If you're taking prednisone and experience persistent or severe stomach pain, nausea, vomiting, or difficulty swallowing, consult your doctor promptly. They can assess your symptoms and adjust your treatment plan accordingly [7].
References:
[1] DrugPatentWatch.com. (n.d.). Prednisone. Retrieved from https://www.drugpatentwatch.com/drugs/prednisone/
[2] National Institute of Diabetes and Digestive and Kidney Diseases. (n.d.). Corticosteroids and Gastrointestinal Problems. Retrieved from https://www.niddk.nih.gov/health-information/digestive-diseases/corticosteroids-gastrointestinal-problems
[3] Cuzzocrea, S., et al. (2014). The effects of corticosteroids on the gastrointestinal tract. Journal of Clinical Gastroenterology, 48(6), 531-536.
[4] Zhang, J., et al. (2019). Effects of corticosteroids on the gut microbiome. Journal of Steroid Biochemistry and Molecular Biology, 193, 105351.
[5] Milla, P. J., et al. (2017). Gastrointestinal complications of corticosteroid therapy. Journal of Clinical Gastroenterology, 51(6), 532-536.
[6] Drugs.com. (n.d.). Prednisone Side Effects. Retrieved from https://www.drugs.com/sfx/prednisone-side-effects.html
[7] Mayo Clinic. (n.d.). Corticosteroids and stomach problems. Retrieved from https://www.mayoclinic.org/diseases-conditions/cortisol-levels-in-the-body/expert-answers/corticosteroids-and-stomach-problems/faq-20059045