Can you take farxiga and entresto together?

Yes. Farxiga (dapagliflozin) and Entresto (sacubitril/valsartan) can be taken together. There are no known significant drug–drug interactions between them, and many people with heart failure take both.

What to know when using them together:
- Both can lower blood pressure and affect kidney function, so your doctor will likely monitor your blood pressure, kidney function (creatinine/eGFR), and electrolytes (potassium).
- They can increase the risk of dehydration or dizziness, especially if you’re also taking diuretics.
- Dapagliflozin can cause genital yeast infections; sacubitril/valsartan can cause angioedema (rare). If you notice swelling of the face or tongue, severe dizziness, or trouble breathing, seek medical care.
- Your doctor may adjust diuretic dosing or other meds when starting or combining these therapies.

When to contact a healthcare professional promptly:
- Fainting, severe dizziness, very small urine output, swelling, or rapid weight gain
- Severe hyperkalemia symptoms (muscle weakness, palpitations)
- Symptoms of angioedema (facial swelling, trouble breathing)

If you want, tell me more about your other meds, kidney function, blood pressure, or what condition you’re treating, and I can tailor the information.