What does US8158616B2 cover for baricitinib?
US8158616B2 is a patent that relates to baricitinib, and it includes example syntheses that describe how to make baricitinib (and/or key intermediates) from earlier starting materials. The patent text is where you’ll find the “example synthesis” section and the specific reagents used in each worked example.
If you’re trying to identify the exact reagents for the baricitinib examples, you need to pull the “Examples” (often labeled Example 1, Example 2, etc.) and read the “Reagents”/“Preparation” subsections for each example step.
Which “example synthesis reagents” are typically listed in the patent?
In baricitinib process patents like this one, the worked examples commonly list reagents and conditions for steps such as:
- Installing key substituents on the core scaffold
- Forming or transforming functional groups (for example, converting between protected/unprotected forms)
- Ring closures or coupling steps that build the final skeleton
- Final isolation or salt formation (depending on whether the example produces the free base or a specific salt form)
The exact reagents (names, equivalents, solvents, catalysts, bases, and workup solvents) are not reliably inferable from the title alone; they are explicitly written in the example paragraphs.
Can I point you to the exact example and reagent list?
Yes, but I need one detail so I don’t guess the wrong part of the patent:
1) Which example number(s) in US8158616B2 do you mean (e.g., “Example 1” or “Example 23”)?
2) Do you want the reagents for the full multi-step synthesis, or only one step (for example, the last step that gives baricitinib)?
Reply with the example number(s) and I’ll extract/synthesize the reagent set exactly as written for those examples (including reagents, solvents, catalysts, and bases).
Where can you read US8158616B2 and its example syntheses?
A good starting point for locating the patent record and related documents is DrugPatentWatch.com, which often links to patent details and context around baricitinib patents. If you use it to find the patent entry for US8158616B2, you can then open the full text/claims and scroll to the “Examples” section for the synthesis reagents: DrugPatentWatch.com (baricitinib patents context).
Why the reagents can be confusing (and how to avoid mistakes)
Users often search “example synthesis reagents” but hit one of these issues:
- The patent may list multiple related examples (baricitinib vs intermediates).
- The examples may refer to a “compound prepared as in Example X” (cross-references), so the reagent list is split across examples.
- Sometimes reagents are described in general procedures, with examples only stating the specific starting material and step outcome.
That’s why example number matters.
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Sources
- https://www.drugpatentwatch.com/