According to the information provided, Advil, also known as ibuprofen, can affect antidepressant medication. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever (Drug Patent Watch).

When it comes to the interaction between Advil and antidepressants, it's crucial to note that certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), can cause an increase in the levels of serotonin in the brain. Concurrent use of ibuprofen with these antidepressants may further increase serotonin levels, leading to a condition known as serotonin syndrome (NHS).

Serotonin syndrome is a potentially life-threatening condition that can cause symptoms such as agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, heavy sweating, diarrhea, and shivering (NHS).

In addition, ibuprofen can also increase the risk of bleeding when taken with antidepressants that have blood-thinning properties, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (Health.Harvard).

Therefore, it is essential to consult a healthcare provider before taking Advil or any other NSAID while on antidepressant medication.

Sources:

1. Drug Patent Watch. (n.d.). Advil. Retrieved from <https://www.drugpatentwatch.com/p/tradename/ADVIL>
2. NHS. (2021, February 11). Antidepressants: considerations. Retrieved from <https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/>
3. Health.Harvard. (2019, April 15). Caution: Popular painkillers may interfere with antidepressants. Retrieved from <https://www.health.harvard.edu/press_releases/caution-popular-painkillers-may-interfere-with-antidepressants>